Hi, please have a look at the read_inventory() function, and the tutorial section on reading seismograms.
To read a miniSEED file:
from obspy import read
stream = read('/path/to/mseed')
You can load a Shake response file by reading a URL like this:
Note: you will have to replace R24FA with the name of your shake
from obspy import read_inventory
inv = read_inventory('https://fdsnws.raspberryshakedata.com/fdsnws/station/1/query?network=AM&station=R24FA&level=resp&format=xml')
To remove the response:
stream.remove_response(inventory=inv, output='VEL')